Location: OSK Metalist Stadion, Kharkiv
Kick-off time: 21:45 CET, 2:45 EST
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This one is huge, no ifs and or buts about it—victory on the road will make the return fixture infinitely more manageable—so we have to hope that the momentum Roma has accrued during the soft part of their domestic schedule will carry over to the Round of 16.